UH Med Now

Pictured: Dr. Stokes in his laboratory at JABSOM.

A Nevada company is hoping to develop new medicines for heart failure using compounds in marijuana and a novel therapy identified by a University of Hawaii (UH) researcher.

Dr. Alexander Stokes, Assistant Research Professor in the Department of Cell and Molecular Biology at the John A. Burns School of Medicine at UH, obtained a U.S. patent for his novel therapy in 2015. The patent claims the cannabinoid receptor TRPV1 can be regulated therapeutically by plant-based cannabinoids. Cannabinoids include psychoactive and non-psychoactive compounds derived from marijuana, both of which have medicinal properties. They exert their effects inside cells after binding to receptor proteins in the cell membranes, such as TRPV1 and the classical cannabinoid receptors, CB1 and CB2.

Pharmaceutical development company GrowBlox Life Sciences, LLC, a wholly owned subsidiary of GB Sciences, Inc., obtained the license for Stokes’ intellectual therapy last December from Makai Biotechnology, LLC, a Hawaii-based cardiovascular therapy company founded by Stokes.

Patients urgently need new drugs that can prevent or reverse the stages of cardiac disease and heart failure, according to Dr. Stokes.

“Cardiovascular disease is the leading global cause of death, accounting for more than 17.3 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030,” said Dr. Stokes. In the U.S, he explained, this equates to one in three deaths, about one every 40 seconds, and costs the country approximately $316.6 billion a year.

Patients urgently need new drugs that can prevent or reverse the stages of cardiac disease and heart failure, according to Dr. Stokes. He further explained that TRPV1 is clearly a major cellular receptor involved in the progression to heart failure, and there is great potential for the new, proprietary mixtures within the GB Life Sciences portfolio to regulate the TRPV1 cannabinoid receptor.

GB Sciences said licensing the TRPV1 patent is a major step in its commitment to discovering new drugs that interact with the non-classical cannabinoid receptors, in addition to binding to the better characterized CB1 and CB2 cannabinoid receptors.

The ‘entourage effect’ has clinical benefits

“Our vision of novel, patentable cannabis-based formulations in the treatment of major diseases is now married with a proven drug target for modulation of adverse outcomes in cardiovascular disease,” said Dr. Andrea Small-Howard, Chief Science Officer of GB Sciences

Cannabinoids in native plant extracts exerted a more significant effect on TRPV1 receptors than purified cannabinoids in published research reports.

“GB Sciences believes its cannabis-plant-based approach may provide additional clinical benefits to patients due to the ‘entourage effect’. In addition, the side effect profiles of cannabis-based therapies have generally been well tolerated,” said Dr. Small-Howard. The ‘entourage effect’ refers to the theory that some cannabis compounds have greater effects on the human body when combined with other compounds than when given alone.

GB Sciences CEO John Poss remarked: “This license is an important step in our Company’s march to successful drug discovery. We are very proud of Dr. Small-Howard and her team, and we expect results from this effort that will enable the company to do well by doing good for literally millions of cardiac patients around the world.”

About GB Sciences, Inc.
GB Sciences, Inc. (GBLX) is a diverse cannabis company, focused on cultivation as well as biopharmaceutical research and development. The Company’s goal is creating safe, standardized, pharmaceutical-grade, cannabinoid therapies that target a variety of medical conditions.

About Makai Biotechnology, LLC
Makai Biotechnology, LLC is a Hawaii-based cardiovascular therapy company established by Dr. Alexander J. Stokes, Assistant Professor at the University of Hawaii, John A Burns School of Medicine. Makai Biotechnology is developing novel therapies for the treatment of heart failure. A novel ion channel target has been identified that modulates heart disease. Under the direction of Dr. Alexander Stokes, Makai Biotechnology has validated multiple effective compounds that regulate this target. Makai Biotechnology plans to establish alliances with major pharmaceutical companies to develop and test compounds from pre-clinical through phase II human clinical trials.

Note:
The John A. Burns School of Medicine supports preservation of the Native Hawaiian Language. We respectfully use proper Hawaiian diacritical marks where we can. On-line, we may neglect them in some instances to increase search ability on the internet. Where possible we also will include versions of the word (perhaps in parentheses) with its proper markings.