JABSOM Faculty & Staff
Ralph Victor Shohet:
|Position: Professor, Director of Cardiovascular Research|
|Bio: 1983-85:Resident in Internal Medicine, Parkland Memorial Hospital, Dallas, TX|
1985-88:Medical Staff Fellow, with Dr. Robert Adelstein, NIH/NHLBI, Bethesda, MD, studying molecular biology of contractile proteins
1989-90:Postdoc Fellow, with Dr. Joseph Sambrook, Dept of Biochemistry, UTSWMC, studying cardiac development and thrombolysis
1990-91:Clinical Cardiology Fellow, Parkland Hospital, Dallas, TX.
1992-02: Assistant Professor of Medicine, Division of Cardiology, UTSWMC
2002-2005: Associate Professor of Medicine (with tenure), Division of Cardiology, UTSWMC
2004-2005: Associate Professor of Molecular Biology, UTSWMC
2005-present: Professor of Medicine, Director of Cardiovascular Research, JABSOM
|Education: 1975-79: Harvard College, degree: BA in American History|
1979-83: University of California, San Diego, degree: M.D.
|Research Areas: Projects Underway in the Lab|
1. ET-1: We have discovered that mice with cardiac deletion of the endothelin gene develop heart failure with stress or age. This raises important questions about the role of ET-1 in cardiac function and the direction of strategies to block endothelin receptors that are now in clinical trials. We are presently trying to sort out the connections between endothelin signaling and cardiac myocyte survival.
2. UTMD: We are developing ultrasound-targeted microbubble delivery of biologically active molecules. Cavitation of these bubbles as they pass through organs of interest allows us to deposit expression constructs or proteins with high specificity.
3. In vivo analysis of endothelial transcription: Using a transgenic animal with endothelial expression of GFP and FACS we can assess endothelial gene regulation generated by various stimuli in the living animal. These studies form the basis of a recently funded project looking at the endothelial response to pollutants. We are also applying this method to the elucidation of gene regulation in smoking, aging and hypercholesterolemia.
4. Human genetics: I have participated in a genome-wide genotyping effort directed at coronary artery disease with my colleague Jonathan Cohen. I hope to further confirm and evaluate candidate loci in diverse ethnic populations here in Hawaii.
5. Angiogenesis: We have created a tet-inducible, cardiac-specific, oxygen-stable, HIF1a mouse strain and are using it to evaluate the transcriptional and physiological effects of HIF overexpression.