Takashi Matsui, MD PhD

Takashi Matsui, MD, PhD

Professor

Chair, Department of Anatomy, Biochemistry and Physiology

 

Graduate Faculty:
Developmental and Reproductive Biology (DRB)
Cell and Molecular Biology (CMB)

Phone: 808-692-1554

Fax: 808-692-1951

Email:  tmatsui@hawaii.edu

Address:
651 Ilalo St., BSB 110A, Honolulu, HI96813

 

Research projects:

The role of mammalian target of rapamycin (mTOR) in the heart, Cardiac cell signaling controlling cell survival, Diabetic hearts

Heart failure is a leading cause of hospitalization and mortality. We are examining changes in signal transduction pathways caused by myocardial infarction and cardiac hypertrophy, two important precipitants of heart failure. Specifically, we explore the role of the mammalian target of rapamycin (mTOR), which is intimately related to the insulin/phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway, in cardiomyocyte cell death and function under stressed conditions.

 

 

Figure1: A. ex vivo isolated heart perfusion (Langendorff perfused heart) B. Isolated adult cardiomyocytes expressed with green fluorescent protein (GFP)

Figure 2: Intramyocardial Fibrosis (blue) observed in post-Myocardial Infarction. (Masson’s trichome staining)