Takashi Matsui, MD PhD
Takashi Matsui, MD, PhD
Chair, Department of Anatomy, Biochemistry and Physiology
The role of mammalian target of rapamycin (mTOR) in the heart, Cardiac cell signaling controlling cell survival, Diabetic hearts
Heart failure is a leading cause of hospitalization and mortality. We are examining changes in signal transduction pathways caused by myocardial infarction and cardiac hypertrophy, two important precipitants of heart failure. Specifically, we explore the role of the mammalian target of rapamycin (mTOR), which is intimately related to the insulin/phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway, in cardiomyocyte cell death and function under stressed conditions.
Figure1: A. ex vivo isolated heart perfusion (Langendorff perfused heart) B. Isolated adult cardiomyocytes expressed with green fluorescent protein (GFP)